Los Poblanos Ranch, which forms the main part of the Los Poblanos National Historic District, encompasses Los Poblanos Inn, La Quinta Cultural Center, and the rich agricultural fields that Los Poblanos Organics now call home.

The Los Poblanos land was originally inhabited by Anasazi (Ancestral Pueblo Indians) in the 14th century. Around 1716, it was deeded to Elena Gallegos de Gurulé as part of the Elena Gallegos land grant., which stretched from the North Valley to the Sandia Mountains. Many of the original Mexican settlers in this area were thought to have come from the state of Puebla whose citizens are known as "Poblanos", thus the land's name.

Los Poblanos is first mentioned by name in a 1790 census which shows six plazas, or settlements, in the North Valley of Albuquerque, including La Plaza de San Antonio de Los Poblanos. Ambrosio and Juan Cristobal Armijo owned the 500-acre Los Poblanos Ranch through the 19th Century. The Ranch comprised what are now the Caballero, Tinnin Farm, and Los Poblanos Orchard developments. Albert and Ruth Simms reassembled the Ranch in the 1930s. Albert Simms and Ruth Hanna McCormick were widowers when they met while both serving terms in the U.S. Congress.

Returning to New Mexico in 1934, Albert and Ruth reunited much of the original Los Poblanos land and hired famous architect John Gaw Meem , the "Father of Santa Fe Style," to design the remodel of the ranch house (now the Inn) and to design La Quinta.

The Los Poblanos Ranch is the original site of Albuquerque’s historic Creamland Dairy. The dairy began as an effort to lessen dependency on the importation of milk and cream from other states. The Simms were ardent advocates for education in Albuquerque. They launched schools in Albuquerque that are still vibrant academic centers: Manzano Day School, Sandia School, and Albuquerque Academy (Farmer Monte’s alma mater). The Simms’s contributions and devotion to their city have had lasting effects enjoyed even today by all Albuquerqueans.

Ruth died in 1944, and Albert remained on the farm until his death in 1964. His nephew, Albert Simms, with his wife Barbara and their five children, moved to Los Poblanos in 1966. In 1976, the ranch was split and sold to Armin and Penny Rembe and Armin's sister, Victoria Rembe Walker, and her husband, Robert Walker. The Rembes reunited the property in 1997.

In order to preserve and protect the historic property, the ranch house has been converted into the Los Poblanos Inn. The La Quinta Cultural Center was brought back to its original use as a building for public use and recreation. The gardens have been improved, and the fields have been again dedicated to agricultural use. The Rembes remain committed to serving as the ranch's stewards and are also avid, long-time collectors of New Mexican and Latin American artifacts.